Cachexia is a multifaceted condition characterized by persistent muscle loss that cannot be completely reversed through standard nutritional support, resulting in a decline in functionality. It may be masked by excess weight, obesity, fluid retention, or tumor mass. Anorexia indicates a decreased appetite, commonly observed in cancer patients, although its exact frequency remains uncertain.
When cachexia primarily occurs due to reduced intake, it is termed cancer-related cachexia and anorexia syndrome (CACS), which encompasses muscle wasting, lipolysis, and diminished food consumption, distinguishing it from simple cachexia.
Some researchers suggest that cannabis from Buy My Weed Online Canada could enhance appetite and alleviate nausea in cancer patients.
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Key Takeaways:
- THC capsules from Buy My Weed Online Canada could assist cancer patients in consuming more food and feeling less nauseated, thereby improving their quality of life.
- Studies show that cannabis influences brain cells responsible for hunger, potentially aiding appetite issues in cancer patients and others.
- THC capsules provide precise dosing, convenience, privacy, and long-lasting effects, making them perfect for medical marijuana users who prefer not to smoke.
Cancer Cachexia and Anorexia Syndrome
Cachexia is a condition identified by significant weight loss due to the depletion of muscle and fat, frequently seen in patients with advanced illnesses such as heart failure, HIV/AIDS, COPD, kidney failure, and particularly cancer.
This often coexists with anorexia, which refers to a reduced appetite resulting in at least a 5% decrease in body weight. Together, they constitute cancer anorexia-cachexia syndrome (CACS).
Hospitalized cancer patients typically exhibit poor nutritional intake, with nearly half facing malnutrition or being at risk. Cachexia not only reduces the quality of life for patients but also obstructs treatment and can hasten the end of life. Its prevalence escalates sharply as death approaches, with cachexia identified as a leading cause of death in over 20% of cases.
Despite its common occurrence, CACS frequently goes unnoticed and untreated in clinical environments due to vague definitions, diagnostic criteria, classification systems, and approved therapies. Clinicians evaluate a patient’s nutritional status using various metrics like body weight, skinfold thickness, and mid-arm circumference, although body weight is often the primary measure, typically using inappropriate reference weights.
Treatment
The most apparent approach to tackle anorexia is enhancing nutrition – yet evidence supporting its efficacy is limited. For cancer patients, nutritional care involves:
- Dietary Counseling
- Oral Supplements
- Enteral and Parenteral Nutrition
However, success varies based on the type and stage of cancer.
Pharmacological Approaches
At present, there are no confirmed medications for treating Cancer Anorexia-Cachexia Syndrome (CACS), but some drugs are utilized off-label or are currently in clinical trials. These medications fall into four categories based on their mechanisms:
- Appetite Stimulants
- Cytokine Modulators
- Anabolic Agents
- Combination Therapies
Furthermore, megestrol acetate, a progestin, is separately employed due to its unclear mode of action.
Cannabis in Medicine
The cannabinoid could enhance the lives of cancer patients and pave the way for future treatments. This offers hope for cachexia patients, a condition where appetite loss leads to malnutrition. It provides relief without intoxicating effects, making it a potential remedy for these patients.
Various cannabis formulations with differing effects are available, including inhaled THC for quick effects and orally ingested THC for slower absorption and prolonged effects. Sublingual administration delivers rapid onset lasting 2 to 4 hours.
Clinical Trial
A study conducted by researchers from Israel and the United States evaluated how cannabis pills influence CACS in advanced cancer patients. This finding significantly impacts the treatment of appetite disorders faced by cancer patients, individuals with anorexia, and potentially obesity.
Methods
The study utilized cannabis capsules containing two types of oil-based compounds. They planned to treat participants with 10 mg doses twice daily for six months, which included 9.5 mg of tetrahydrocannabinol (THC) and 0.5 mg of cannabidiol (CBD).
If participants encountered side effects, the dose would be reduced to 5 mg twice daily (4.75 mg THC and 0.25 mg CBD). At each doctor’s appointment, they recorded participants’ weight. The primary objective was for participants to gain at least 10% more weight than their initial weight.
Results
Out of 24 patients who consented to participate, 17 began treatment with cannabis capsules. However, only 11 continued for over two weeks. By the study’s end, 3 out of 6 patients who completed the treatment met the primary goal of gaining at least 10% more weight. The weight of the remaining three patients remained unchanged.
Tumor necrosis factor-α (TNF-α), an inflammation marker, decreased following the treatment. Patients reported improved appetite and mood, alongside reduced pain and fatigue.
Despite several challenges, this initial study demonstrated a weight gain of 10% or more in 3 out of 17 patients (17.6%) taking daily doses of 5 mg without notable side effects. These results support the need for a larger, more controlled study on cannabis capsules in patients with CACS.
Cannabis Capsules
If you prefer edibles, cannabis flowers, or classic pre-rolls, it’s always exciting to explore new ways to enjoy cannabis.
THC capsules represent one of the latest innovations in the cannabis market. These capsules are cannabis pills containing a precise THC dosage, created from a concentrated cannabis extract combined with a neutral oil. They are similar to cannabis tinctures in capsule format (also referred to as cannabis oil capsules or THC pills).
Key Components
- Cannabis Extract: This concentrated extract derives from the cannabis plant through a method selected by the manufacturer. THC capsules are high in THC, though some may contain only CBD or varying CBD/THC ratios.
- Neutral Oil Suspension: As THC is not soluble in water, it is suspended in oil for optimal absorption by the body. The most common oils used are medium-chain triglycerides (MCT oils), which assist digestion and absorption.
Benefits
Medical marijuana patients and recreational users can benefit from cannabis capsules. They offer:
- Convenience: Consuming a cannabis capsule is as simple as any other oral supplement. Just swallow it with water, no fuss.
- Precision Dosage: For medical users, precise control over cannabinoid intake is essential for achieving desired effects. With THC capsules, each dose is measured, eliminating uncertainty.
- Smoke-Free Option: Many individuals prefer to avoid smoking or vaping for personal or health reasons. THC capsules provide a smoke-free alternative, suitable for those with respiratory concerns.
- Longer Effects: Capsules typically deliver longer-lasting effects compared to smoking or vaping, making them ideal for sustained symptom relief over several hours.
Cannabis Capsules vs. Other Forms of Medicinal Cannabis
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Frequently Asked Questions
What are the different types of capsules?
One more advantage of cannabis pills/capsules is their versatility – formulators can create various capsule types for consumers to select from. This means you can find capsules that suit your personal preferences.
- 1:1 Capsules: These capsules provide an equal THC to CBD ratio in each dose. They can be made with sativa or indica strains and come in various concentrations like 5 mg, 20 mg, 50 mg, or 100 mg cannabinoids per capsule.
- 3:1 Capsules: These capsules deliver a ratio of 3 parts CBD to 1 part THC in each dose.
- THC Capsules: These capsules contain THC exclusively, with varying concentrations per capsule, created from different Sativa or Indica strains to offer specific effects.
- CBD Capsules: These contain only CBD, without THC, and do not induce mind-altering effects. They are designed for individuals seeking the advantages of CBD alone.
How do capsules interact with your body?
- The capsule’s outer shell disintegrates in your digestive tract upon consumption.
- The capsule’s contents are absorbed into the bloodstream.
- THC (and other cannabinoids) are metabolized in the liver.
How long does it take for cannabis capsule effects to kick in?
Generally, THC capsules take around 90 minutes to begin showing effects. The effects can last from 5 to 12 hours, gradually decreasing in intensity. Compared to inhaled cannabis, capsule effects tend to last twice as long on average.
However, experiences may vary based on factors like age, medications, personal cannabis tolerance, and cannabinoid composition. Some users also observe differing effects based on specific cannabinoids present, potentially due to the “entourage effect.”
How to mail order marijuana?
To mail order recreational cannabis, find a trustworthy delivery service online that offers high-quality cannabis products. After selecting your products, choose “order cannabis delivery,” and a delivery driver will safely bring your order. Ensure the service is reputable for a smooth purchasing experience.
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